Pregnancy #7February 28, 2006 12:21 pm

Final beta & progesterone tomorrow - the anxiety doesn’t let up at all. 

I’m pondering what to do about scans, but then panic & think I’m getting ahead of myself completely. I have an NHS (free) one on the 9th of March - they won’t measure the HR & will calculate from LMP not ovulation day (so I’ll be 3-4 days behind what I should be). I got my first clot at 9 weeks last time. So maybe a private scan at 8 weeks? Or wait until 9? Ha ha if I get that far.

I’ve just booked a holiday for the week starting October the 23rd - EDD is 27th - lets hope we lose the deposit.

ETA (and this is really morbid) - I find myself part of a ‘due in’ pregnancy club (of infertiles), I didn’t mean to & I never have before but some how I am. Anyway there are 28 of us posting, what proportion will miscarry? 25%? About seven of us? One is out already, I wonder how long until I join her? I feel like we’re all posting & being ’supportive’ and at the sma etime sitting at home saying ‘please not me, please not me’; it is very odd.

I’ve got a lot of symptoms now, progesterone boobs still but I’m very tired, sick, emotional & bloody clutzy (I burnt the toast for breakfast three time this morning). If I’m going to lose this one at least I shouldn’t have weeks of feeling crap first.

Pregnancy #7February 25, 2006 4:05 pm

Forth beta

22dpo = 3157 (different lab)

I know I said I wouldn’t - but this time more information is good. I hightailed it back to my RE today - I got a hug & a 15 minute consultation (no scan yet) for free (admittedly it was in the corridor but sometimes I can’t figure the place out, they can be so absolutely perfect & supportive or a complete disaster). The doubling time is back to 41 hours.

My full blood count is okay (on top of clotting problems I have ITP which mean my platelets can fall to 80 something for no reason at all) so I’m staying on clexane & aspirin. After a long chat about it I feel like it is the right thing to do for the time being, if we have bleeding we will re-consider. I can stay off the steroids which is good.

Yet again the progesterone is causing problems. When the last beta came back lower than I wanted I increased my prometrium from 200mgx2 to 200mgx3 a day - despite this it has fallen to 21 (it may well have gone lower then started to rise again). I’m going to increase again & see if I can stabilise it; I’m re-testing on Tuesday & if it isn’t >25 I’m back on the PIO. My gut says the progesterone issues that I seem to have are autoimmune & do affect the welfare of the embryo (rather than just prolonging a doomed pregnancy which is the prevailing attitude in the UK when it comes to supplementation). I found this; I know Dr Beer isn’t perhaps the most respected scientist when it come to evidence based medicine, but I do think the progesterone issues he talks about are relevant to me. 

I’m not planning anything for this pregnancy (it was my birthday yesterday and I  went out for a lovely meal with my parents & Simon and *shock* had a very nice glass of red wine (a lovely Zinfandel)), we’re not telling anyone, we’re just seeing what happens next.

Pregnancy #7February 23, 2006 11:15 am

12dpo = 80

14dpo = 205

19dpo = 944

Doubling time has really slowed down (56 hours now (47 hours from the first beta)) from 36 hours, and it looks like it is starting to go wrong now. It should still be doubling much faster than that, I think it is over 1200 that it starts to slow down. Fucking betas!

No more betas, scan is booked for 9th Match.

We’ve increased the heparin & prometrium, it might be some kind of immune flare; but I feel like I’m grasping at straws (again). Simon keeps reminding me how much better it is than last time (& it is - at 20dpo it was 166), my beta now is what it was exactly a week later. Trouble is, it doesn’t work that way, being better doesn’t really mean anything.

Last time there was definitely something odd going on with the placenta - shit betas, growth restriction, retroplacental clots & then the abruption. That could be caused by the NK issues, the APS or even by the anticoagulation. I feel that we’re headed down the same path, & with no real plan or more information it looks doomed again.

Pregnancy #7February 22, 2006 12:58 pm

I had the blood taken this morning (19dpo, a week since the last one), I still haven’t got any pregnancy symptoms. Tbh I’m trying to ignore the whole thing as much as possible - I nearly didn’t go for the beta today, I’m not sure what good it’ll do.

I’ve been trying to stay away from the computer as much as possible - I am powerless as far as this pregnancy goes, I just want to get through intact. I can’t help comparing myself to other people. This is the beginning of crunch time for me - 5w 5 days tomorrow.

I’ve finished a week long course of dexamethasone - in the hope that it’ll damp down any NK flare I get (my levels had gone back to normal by 6 and a half weeks last time), we aren’t going to be using IVIg this time. I’m still taking aspirin everyday and a very low dose of clexane (lovenox) I am so unsure about this - I’m convinced it contributed to the mc last time. I’ve had another APS check and if the levels come back normal (they’ve only been elevated once out of four tests now) I’m stopping it asap. I’m also taking two prometrium suppositories a day.

Pregnancy #7February 20, 2006 2:23 pm

We’re raising the stakes here:

14dpo = 205

Doubling time is around 35 hours.

Did I say holy fuck?

Now let me continue to count the ways this can go wrong … but holy fuck it doubled!!!

Repeat tomorrow (need to be >850) - still no symptoms & pee sticks aren’t darker.

Pregnancy #7 12:32 pm

I was supposed to get the results back an hour and a half ago - but apparently they are ‘too busy’ and I need to wait another hour (what’s the betting I call back when they are all out at lunch).

Now I’m worried that they didn’t tell me because they need a few minutes for tthe bad news ‘counselling’, arrrgggghhh this is hard.

Pregnancy #7February 19, 2006 3:59 pm

Stupid question really, none of us have done anything to deserve it, but I’m now realising how ill equiped I am to deal with getting bad news.

I cried for many hours last night - I am not in a good place to deal with another loss. If I thought that there was any realistic chance of the clomid/inj cycle working I wouldn’t have done it.  

The tests are not getting darker - the ones today are the same as when I got a beta of 130 last time, it need to be double that by now if there’s an chance of it working out.

I have no symptoms apart from sore boobs (?progesterone).

At least tomorrow it should be over one way or another.

Oh I almost forgot - if (hell freezes over etc) this pregnancy continues my first scan is booked for March 9th, the day we are going to our first recurrent loss group. I’m taking that as a bad omen.

Pregnancy #7February 18, 2006 5:00 pm

I’ve used up the last of my hpts, which is a blessing really because I won’t buy any more & I simply can’t resist them while they are in the house. I must pee.

I don’t know if the lines are getting darker, they should be, but I can’t say for sure they are. They were definitely darker between 12dpo & 15dpo, but I can’t tell if they are still darkening. The lines aren’t as dark as the controls yet. I’m trying to make myself believe that it doesn’t mean anything, but I’m not doing very well at it.

Hell! When is someone going to produce a quantitive beta HCG test for home use? Think of the environmental benefits of not wasting all that plastic. Not to mention the improvement in mental health. 

I need to know the next beta number, but I don’t want to because that might mean it is the end and that would just suck.

I’m taking 2x 100mg prometrium suppositories twice a day (better safe than sorry) - so of course I’m convinced that any symptoms I have are just the progsterone talking.

Pregnancy #7February 17, 2006 2:33 pm

I am so not being cool & calm & collected, Zen doesn’t apply here.

12dpo HCG = 80

I had it drawn again today (14dpo). First +ve hpt was at 11dpo on the 14th, it was an ultra sensitive test (10iu) strip & the line was pretty faint. At 12dpo the line was darker but still what I’d describe as faint, yesterday (13dpo) it was much darker so I’m assuming in increased from 80. But today the line is exactly the same - both taken with fmu, if anything the urine was more concentrated today. You see where I’m going? It should have got darker, it didn’t, the beta from today needs to be >160 … what if it isn’t?

And symptoms … ha ha … symptoms 11dpo nothing I got the shock of my life when I saw the second line. 12dpo, my boobs hurt a bit when I walked to the car = good (in my warped habitual aborter mind); 13dpo we’ve hit pay dirt - I hurled my tea & prenatals! Yes! Game on! Today - 14dpo - nothing, I am in fact freaking & I feel so completely normal that I quite fancy a margarita.    

Damn - where’s the acceptance when you need it?

ETA - I just did another one (groan) much less concentrated wee, line is still as dark. This is really dull isn’t? BUT I have also managed to find the conversion from UK to US units for progsterone

http://www.unc.edu/~rowlett/units/scales/clinical_data.html

So my progesterone (with no supplementation) was 33.3, I think that’s pretty good at least (it was a measly 14.1 with masses of cycolgest last time).

Oh & can I be more like Jo please?

1000 miles., Pregnancy #7 1:09 pm

I’m pregnant again. A bit pregnant anyway, I’m waiting for my second beta. This is a relatively ‘natural’ pregnancy (superovulation (puregon/menopur)); how odd that is that I’d consider injecting myself with purified urine a natural way of getting pregnant but it didn’t involve ovarian puncture or anaesthesia & there was a penis involved so I’ll take it. This is my seventh pregnancy, I have no reason to believe that it will result in a child, it is fairly likely that I won’t get good news on Monday; but for the next few days I am pregnant.

My gynaecologist describes my history as grim, I agree and with him; I’ve had a veritable smorgasbord of miscarriages.

September ‘98 - blighted ovum, discovered at 8 weeks.

November ‘00 - a live birth! With a pregnancy blighted by hyperemesis, pre eclampsia, pPROM, preterm (EMCS) delivery, ABO incompatibility, a short stay in the SCBU & devastating post natal depression. 

June ‘02 - miscarriage at 5 weeks, pretty standard +hpt followed by bleeding.

December ‘02 - missed miscarriage at 13 weeks, the baby died around at 8 weeks, we got a heart beat this time but it didn’t last.

May ‘03 - another 5 or 6 week loss.

We then had 2+ years of horrific, unremitting infertility. It was honestly the hardest time of my life, everything suffered, I became a different person sad & hopeless. Our SIF is unexplained, I may have some slight immune problems, maybe PCOS, our in vitro fertilisation isn’t good, but no one can explain why.

November ‘05 - an ICSI cycle resulted our daughter Estella. Things didn’t go well from the start with low & non doubling beta HCGs, then a heartbeat but slow growth, then the growth caught up but I started bleeding from a subchorionic haematoma. Eventually I had a pPROM & placental abruption & we lost the baby at 14 weeks. We threw everything at this pregnancy, IVIg, steroids, aspirin, heparin, progesterone; it still didn’t work. We lost her twin very early in the pregnancy.

So now I find myself, only 3 months later, pregnant again & to be honest I don’t know what I feel. I’m gratefully accepting another chance but I almost can’t imagine it working.